Aldolase and Protease: Unsuspected Structural Homology
نویسندگان
چکیده
منابع مشابه
HIV Protease Structural Database
The HIV Protease Database (HIVdb) is an archive of experimentally determined 3-D structures of Human Immunodeficiency Virus Type 1 (HIV-1), Human Immunodeficiency Virus Type 2 (HIV-2), and Simian Immunodeficiency Virus (SIV) proteases and their complexes with inhibitors or products of substrate cleavage. It serves a global community of researchers, educators and students. HIVdb is one of the fi...
متن کاملCucumisin, a serine protease from melon fruits, shares structural homology with subtilisin and is generated from a large precursor.
Cucumisin is a thermostable alkaline serine protease that is found in the juice of melon fruits (Cucumis melo L.). We have determined the complete nucleotide sequence of a cucumisin cDNA (2,552 nucleotides) and deduced the corresponding amino acid sequence. The open reading frame of the cDNA consists of 731 codons and encodes a large precursor (molecular weight, 78,815) relative to the observed...
متن کامل[Aldolase].
OH OH Two main classes of aldolases are found in Nature. Type I aldolases activate the nucleophilic partner by forming an imine as an intermediate; this type of enzyme is found in animals and higher plants. Type II aldolases occur in microorganisms and they require R 2 to be a hydroxy group. These enzymes feature a Zn 2+ ion that promotes the reaction by forming a chelate with both the carbonyl...
متن کاملStructural Homology to Other Sugar Transporters
The MAL61 gene of Saccharomyces cerewisiae encodes maltose permease, a protein required for the transport of maltose across the plasma membrane. Here we report the nucleotide sequence of the cloned MAL61 gene. A single 1842 bp open reading frame is present within this region encoding the 6 14 residue putative MAL61 protein. Hydropathy analysis suggests that the secondary structure consists of t...
متن کاملStructural and functional homology of parvovirus and papovavirus polypeptides.
We have compared the sequences of the putative polypeptides of the human pathogenic B19 parvovirus with protein sequences in the National Bethesda Research Foundation Library, and have discovered a significant homology between a B19 parvovirus non-structural (NS) protein and the T antigens of polyomaviruses and simian virus 40 (SV40) and the putative E1 proteins of papillomaviruses. The region ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 1968
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.161.3843.813